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Literature summary extracted from

  • Keane, F.M.; Yao, T.W.; Seelk, S.; Gall, M.G.; Chowdhury, S.; Poplawski, S.E.; Lai, J.H.; Li, Y.; Wu, W.; Farrell, P.; Vieira de Ribeiro, A.J.; Osborne, B.; Yu, D.M.; Seth, D.; Rahman, K.; Haber, P.; Topaloglu, A.K.; Wang, C.; Thomson, S.; Hennessy, A.; Prins, J.; Twigg, S.M.; McLennan, S.V.; McCaughan, G.W.; Ba, B.a.c.
    Quantitation of fibroblast activation protein (FAP)-specific protease activity in mouse, baboon and human fluids and organs (2013), FEBS open bio, 4, 43-54.
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
3.4.21.B28 additional information generation of FAP gene knockout mice Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.21.B28 extracellular
-
 Papio sp.
-
-
3.4.21.B28 extracellular
-
 Mus musculus
-
-
3.4.21.B28 extracellular
-
 Homo sapiens
-
-

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.B28 Homo sapiens Q12844
-
-
3.4.21.B28 Mus musculus P97321
-
-
3.4.21.B28 Papio sp.
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.B28 adipose tissue
-
 Papio sp.
-
3.4.21.B28 bladder
-
 Papio sp.
-
3.4.21.B28 blood serum
-
 Papio sp.
-
3.4.21.B28 blood serum
-
 Mus musculus
-
3.4.21.B28 blood serum
-
 Homo sapiens
-
3.4.21.B28 brain lowenzyme activity Mus musculus
-
3.4.21.B28 carcinoma cell
-
 Papio sp.
-
3.4.21.B28 carcinoma cell
-
 Mus musculus
-
3.4.21.B28 carcinoma cell
-
 Homo sapiens
-
3.4.21.B28 colon
-
 Papio sp.
-
3.4.21.B28 epididymis
-
 Papio sp.
-
3.4.21.B28 leukocyte lowenzyme activity Mus musculus
-
3.4.21.B28 liver the protease fibroblast activation protein is a specific marker of activated mesenchymal cells in tumor stroma and fibrotic liver Mus musculus
-
3.4.21.B28 liver the protease fibroblast activation protein is a specific marker of activated mesenchymal cells in tumour stroma and fibrotic liver Homo sapiens
-
3.4.21.B28 liver the protease fibroblast activation protein is a specific marker of activated mesenchymal cells in tumour stroma and fibrotic liver. The enzyme activity is 14 to 18fold greater in cirrhotic than in non-diseased human liver, and almost doubled in alcoholic cirrhosis Papio sp.
-
3.4.21.B28 mesenchymal cell the protease fibroblast activation protein is a specific marker of activated mesenchymal cells in tumor stroma and fibrotic liver Mus musculus
-
3.4.21.B28 mesenchymal cell the protease fibroblast activation protein is a specific marker of activated mesenchymal cells in tumour stroma and fibrotic liver Papio sp.
-
3.4.21.B28 mesenchymal cell the protease fibroblast activation protein is a specific marker of activated mesenchymal cells in tumour stroma and fibrotic liver Homo sapiens
-
3.4.21.B28 additional information the protease fibroblast activation protein is a specific marker of activated mesenchymal cells in tumor stroma and fibrotic liver. Highest levels of enzyme activity occur in uterus, pancreas, submaxillary gland and skin, whereas the lowest levels ar found in brain, prostate, leukocytes and testis Mus musculus
-
3.4.21.B28 additional information the protease fibroblast activation protein is a specific marker of activated mesenchymal cells in tumour stroma and fibrotic liver Homo sapiens
-
3.4.21.B28 additional information the protease fibroblast activation protein is a specific marker of activated mesenchymal cells in tumour stroma and fibrotic liver. The enzyme activity is greatly elevated in tumours and associated lymph nodes and in fungal-infected skin of unhealthy baboons Papio sp.
-
3.4.21.B28 nerve
-
 Papio sp.
-
3.4.21.B28 pancreas high enzyme activity Mus musculus
-
3.4.21.B28 prostate lowenzyme activity Mus musculus
-
3.4.21.B28 skin
-
 Papio sp.
-
3.4.21.B28 skin high enzyme activity Mus musculus
-
3.4.21.B28 submaxillary gland high enzyme activity Mus musculus
-
3.4.21.B28 testis lowenzyme activity Mus musculus
-
3.4.21.B28 tongue
-
 Papio sp.
-
3.4.21.B28 uterus high enzyme activity Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.B28 Boc-Ala-Gly-Pro-Arg-7-amido-4-methylcoumarin + H2O
-
 Papio sp. Boc-Ala-Gly-Pro-Arg + 7-amino-4-methylcoumarin
-
 ?
3.4.21.B28 Boc-Ala-Gly-Pro-Arg-7-amido-4-methylcoumarin + H2O
-
 Mus musculus Boc-Ala-Gly-Pro-Arg + 7-amino-4-methylcoumarin
-
 ?
3.4.21.B28 Boc-Ala-Gly-Pro-Arg-7-amido-4-methylcoumarin + H2O
-
 Homo sapiens Boc-Ala-Gly-Pro-Arg + 7-amino-4-methylcoumarin
-
 ?
3.4.21.B28 Gly-Pro-7-amido-4-methylcoumarin + H2O
-
 Papio sp. Gly-Pro + 7-amino-4-methylcoumarin
-
 ?
3.4.21.B28 Gly-Pro-7-amido-4-methylcoumarin + H2O
-
 Mus musculus Gly-Pro + 7-amino-4-methylcoumarin
-
 ?
3.4.21.B28 Gly-Pro-7-amido-4-methylcoumarin + H2O
-
 Homo sapiens Gly-Pro + 7-amino-4-methylcoumarin
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.21.B28 FAP-specific protease
-
 Papio sp.
3.4.21.B28 FAP-specific protease
-
 Mus musculus
3.4.21.B28 FAP-specific protease
-
 Homo sapiens
3.4.21.B28 fibroblast activation protein-specific protease
-
 Papio sp.
3.4.21.B28 fibroblast activation protein-specific protease
-
 Mus musculus
3.4.21.B28 fibroblast activation protein-specific protease
-
 Homo sapiens